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Alan Dombkowski, Ph.D.
Associate Professor Department of Pediatrics Department of Oncology School of Medicine Wayne State University Children’s Hospital of Michigan 3901 Beaubien Blvd. Room 3N47 Detroit, MI 48201 (313) 745-6381 domski@wayne.edu |
Laboratory of Functional Genomics and Bioinformatics
The central theme of our research is integration of functional genomics with computational methods to uncover molecular mechanisms of disease and identify potential therapeutic targets. We are focused on characterization of cellular pathways and signaling events involved in disease progression and pathology. Towards that goal, we develop and apply computational methods to leverage the depth and dimensionality of "omics" data derived from a range of molecular levels, including transcript, microRNA, methylation, and protein. Our ongoing projects include identification of epigenetic events associated with epilepsy in pediatric patients with tuberous sclerosis complex (TSC).
Epilepsy and Tuberous Sclerosis Complex (TSC)We are uncovering molecular events associated with the onset of epilepsy in children with tuberous sclerosis complex.
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BioinformaticsWe have developed bioinformatics tools that are used by labs throughout the world, as well as licensed by pharmaceutical firms.
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Functional GenomicsOur laboratory uses genomics technology to detect genetic changes and cellular events associated with disease onset and progression.
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