Dombkowski Lab
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  • Epilepsy/Tuberous Sclerosis Complex
  • microRNAs
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​NEWS: Bioinformatics software developed by the Dombkowski lab may help expedite COVID-19 vaccine


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Alan Dombkowski, Ph.D.
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Associate Professor
Department of Pediatrics
Department of Oncology
School of Medicine
Wayne State University 

Children’s Hospital of Michigan
3901 Beaubien Blvd. Room 3N47
Detroit, MI 48201

(313) 745-6381
domski@wayne.edu
Affiliations

Department of Pediatrics
Clinical Pharmacology and Toxicology


Translational Neuroscience Program

CURES Environmental Health Center

​Cancer Biology Graduate Program, Molecular Therapeutics

Laboratory of Functional Genomics and Bioinformatics

​The central theme of our research is integration of functional genomics with computational methods to uncover molecular mechanisms of disease and identify potential therapeutic targets. We are focused on characterization of cellular pathways and signaling events involved in disease progression and pathology. Towards that goal, we develop and apply computational methods to leverage the depth and dimensionality of "omics" data derived from a range of molecular levels, including transcript, microRNA, methylation, and protein. Our ongoing projects include identification of epigenetic events associated with epilepsy in pediatric patients with tuberous sclerosis complex (TSC). 

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Epilepsy and Tuberous Sclerosis Complex (TSC)

We are uncovering molecular events associated with the onset of epilepsy in children with tuberous sclerosis complex.
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Bioinformatics

​We have developed  bioinformatics tools that are used by labs throughout the world, as well as licensed by pharmaceutical firms.
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Functional Genomics

Our laboratory uses genomics technology to detect genetic changes and cellular events associated with disease onset and progression. 
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  • Home
  • Functional Genomics
  • Epilepsy/Tuberous Sclerosis Complex
  • microRNAs
  • Bioinformatics
  • People
  • Publications
  • Contact